If MS Dynamics CRM has an ODBC or JDBC driver available for you to use then you can use this as your connection layer. Universes support Generic ODBC and JDBC drivers. The issue you may run into is if the ODBC/JDBC layers are non-standard and do not conform to the standards for these connection layers.
Look around for instructions on how to use ODBC or JDBC with MS Dynamics CRM and you should be able to get this setup.
Thanks
JB