As a long time Crystal user (19+ years), the only benefits that I can see for CR4E are:
1. You can connect it to data using a .UNX universe.
2. It has been optimized for working with BEx queries and HANA.
3. When reports are run inside BusinessObjects or Crystal Reports Server, they run in 64-bit mode and can consume 64-bit data connections (the design tool is 32-bit, though...)
However, you must have either BusinessObjects or Crystal Reports Server to use it. Also, some of the formatting options that you have in what I call "classic" Crystal are not available, you can't use arrow keys to move objects, etc.
I know there are people who like it, but, personally, I avoid it when I can.
-Dell